Table 3. Regression analysis of predictive factors for complicated with severe sepsis in febrile de-compensated cirrhotic patients.
| Parameter at inclusion | Odd Ratio(95% CI) | P values | |
|---|---|---|---|
| (A). Univariate analysis | |||
| Child-Pugh class B+C | 1.23(0.41–2.16) | 0.81 | |
| Moderate+massive ascites | 1.18 (0.82–1.75) | 0.53 | |
| Model of end stage liver disease (MELD) score | 0.943(0.36–1.89) | 0.25 | |
| Plasma acute C-reactive protein level (CRP, mg/dL) | 0.67(0.94–4.67) | 0.79 | |
| Acute physiologic and chronic health (APACH) III score | 1.58(1.04–2.24) | 0.23 | |
| High [sCD14] (>3.7μg/mL) | 1.73 (0.42–2.13) | 0.007 | |
| High [endotoxin] (>2.3 EU/mL) | 1.36 (1.08–2.3) | 0.014 | |
| Subjective global nutritional assessment (SGNA) score>1 | 2.688(0.244–2.87) | 0.029 | |
| Previous spontaneous bacterial peritonitis (SBP) | 0.842(1.18–2.34) | 0.45 | |
| TLR4 +896 A/G, variant(G)–allele carriers | 2.41 (0.275–2.71) | 0.02 | |
| CD14–159 C/T, variant ((T)-allele carriers | 1.82(0.783–2.51) | 0.01 | |
| Double TLR4 +896A/G and CD14 -159C/T variant–alleles carriers | 4.37 (0.25–1.27) | 0.0039 | |
| (B). Multivariate analysis | |||
| Subjective global nutritional assessment (SGNA) score>1 | 3.714(0.737–4.123) | 0.0014 | |
| High [sCD14] (>3.7μg/mL) | 2.198(0.045–2.65) | 0.006 | |
| High [endotoxin] (>2.3 EU/mL) | 3.105(0.89–3.142) | 0.0032 | |
| TLR4 +896 A/G, variant ((G)–allele carriers | 2.967(0.593–5.123) | 0.004 | |
| CD14–159 C/T, variant ((T)-allele carriers | 3.11(0.71–5.2) | 0.001 | |
| Double TLR4 +896A/G and CD14 -159C/T variant–alleles carriers | 5.44(0.065–3.1) | 0.002 | |
SGNA score of >1 (2 to 4) indicated malnutrition; cut-off values for high plasma IL-10 and endotoxin levels were defined as greater than third quartile of data of severe sepsis and non-severe sepsis case.