Table 3. Pooled hazard ratios for PFS according to subgroup analyses.

Outcome subgroup	No. of patients	No. of studies	HR (95% CI)	P value	Model	heterogeneity
						I2 (%)	P
progression-free survival	2905	9	1.74(1.48–2.04)	<0.001	fixed	40.9%	0.095
Ethnicity
Asian	418	4	1.48(0.89–2.48)	0.133	random	57.2%	0.072
Caucasian	2487	5	1.87(1.55–2.25)	<0.001	fixed	11%	0.343
Cut-off value
1.5ULN	2601	6	1.84(1.54–2.19)	<0.001	fixed	5.7%	0.38
Others	304	3	1.4(0.7–2.79)	0.344	random	67.3%	0.047
Analysis type
Multivariate	1750	7	1.67(1.36–2.06)	<0.001	fixed	45.8%	0.086
Univariate	1155	2	1.88(1.30–2.73)	0.001	random	52%	0.149
Tumor type
All stage	836	1	1.58(1.13–2.20)	0.007	fixed	-	-
Metastasis	2069	8	2.02(1.57–2.59)	<0.001	fixed	46.6%	0.069

Abbreviation: DFS = disease-free survival; HR = hazard ratio; CI = confidence interval.