Table 1. Rate Ratios and Number Needed to Treat for Direct Oral Anticoagulants Compared to Warfarin (a).

^a Adapted from Lin, et al., 2015 [9]. Bold values indicate statistical significance (P < 0.05). SSE = Stroke and systemic embolism, CI = Confidence interval, MB = Major bleeding. 

Treatment (Vs. Warfarin)	Rate Ratio (CI) for SSE Overall	Rate Ratio (CI) for SSE in RCTs	Rate Ratio (CI) for MB Overall	Rate Ratio (CI) for MB in RCTs	Number Needed to Treat
Dabigatran, 110 mg	0.80 (0.56-1.13)	0.91 (0.67-1.22)	0.96 (0.68-1.34)	0.80 (0.69-0.93)	385
Dabigatran, 150 mg	0.80 (0.62-1.02)	0.66 (0.48-0.89)	0.96 (0.73-1.26)	0.93 (.081-1.06)	104
Rivaroxaban, 20 mg	0.78 (0.55-1.09)	0.74 (0.55-1.00)	0.97 (0.66-1.42)	1.04 (0.91-1.20)	135
Apixaban, 5 mg	0.82 (0.52-1.31)	0.83 (0.65-1.07)	0.78 (0.46-1.30)	0.70 (0.61-0.81)	207
Edoxaban, 60 mg	0.81 (0.46-1.41)	0.85 (0.65-1.12)	0.81 (.045-1.48)	0.80 (0.70-0.91)	234
No Treatment	1.51 (1.10-2.05)		0.88 (0.36-2.16)	0.96 (0.42-2.16)