Table 11. Examples of biological processes that are brain and nervous system-related.

Enhancer element	ID	Annotation	p-value	Pop. count	Study total	Study count
CGGAAGA	GO:0042428	serotonin metabolic process	0.00027	3	49	2
TCGGAT	GO:0021553	olfactory nerve development	0.00028	2	86	2
AATCGA	GO:0048708	astrocyte differentiation	0.0003	13	54	3
ATGACGA	GO:0060291	long-term synaptic potentiation	0.00031	5	29	2
CGTCGT	GO:0001505	regulation of neurotransmitter levels	0.00036	30	59	4
GGAGAC	GO:0046928	regulation of neurotransmitter secretion	0.00049	4	257	3
GAGAGC	GO:0021983	pituitary gland development	0.0007	9	262	4
CGTCGAC	GO:0090210	regulation of establishment of blood-brain barrier	0.00216	1	11	1
ATGACG	GO:0007212	dopamine receptor signaling pathway	0.00248	5	82	2
TTCGGAT	GO:0007269	neurotransmitter secretion	0.00384	20	24	2
ACCGGGA	GO:0007269	neurotransmitter secretion	0.00718	20	33	2

They resulted of GO enrichment analysis of gene sets that contain putative brain-specific ESEs identified by our approach. Population total is the total number of genes in the population set. In this case, we have 5096 genes in the population set. Pop. count is The number of genes in the population set that are annotated to the GO term in question. Study total is the number of genes in the study set. Study count is the number of genes in the study set that are annotated to the GO term in question.