. 2016 Oct 22;5:e18715. doi: 10.7554/eLife.18715

Table 5.

Contingency tables for analyzing enrichment of SNPs in modeled interfaces. For both the disease-associated and benign sets, the numbers in parentheses are as follows: n11 is the number of SNPs that are interfacial, n10 is the number that are not interfacial, n01 is the number of interfacial unmutated residues and n00 is the number of non-interfacial, unmutated residues. These numbers are used in the odds-ratio and Z-score calculation as described in the 'SNP Analysis' section.

DOI: http://dx.doi.org/10.7554/eLife.18715.018

Disease
	Interfacial	Non-interfacial
Mutated	12,151 (n₁₁)	61,401 (n₁₀)
Non-mutated	298,442 (n₀₁)	2,387,146 (n₀₀)

Benign
Mutated	3554 (n₁₁)	64,656 (n₁₀)
Non-mutated	845,876 (n₀₁)	8,221,708 (n₀₀)