TABLE I.

Preclinical Study to Determine the Effects of Dasatinib on Fertility and Early Embryonic Development

	Male rats			Female rats
			Dasatinib (mg/kg/day)
Drug-related changesa	2.5	5	10	2.5	5	10
Mating rate	NC	NC	NC	NC	NC	NC
Fertility rate	NC	NC	NC	NC	NC	NC
Embryolethality	NC	NC	NC	NC	I	I
Postimplantation loss of embryos	NC	NC	NC	NC	I	I
Seminal vesicle weights with fluid	NC	NC	D	N/A	N/A	N/A
Viability	NC	NC	NC	NC	NC	NC
Mild/moderate dehydration	NC	I	I	NC	NC	I
Body weight (males)	NC	D	D	N/A	N/A	N/A
Body weight gain (females)	N/A	N/A	N/A	NC	D	D
Food intake	NC	D	D	NC	NC	D

^aCompared with untreated controls.

I. increased; D, decreased; NC, no change; N/A, not applicable.