TABLE II.

Preclinical Studies to Determine the Embryo-Fetal Toxicity of Dasatinib

	Rats				Rabbits
	Dasatinib (mg/kg/day)
Drug-related effectsa	2.5	5	10	20	0.5	2	6
Maternal effects
Body weight gain during dosing	D	D	D	D	NC	NC	NC
Body weight gain postdosing	D	D	D	N/A	NC	NC	NC
Body weight postdosing	D	D	D	D	NC	NC	NC
Embryo-fetal effects
Fetal skeletal abnormalities	I	I	N/A	N/A	I	I	I
Embryolethality	I	I	I	I	NC	NC
	NC	No surviving fetuses	NC	NC	I	I NC
	NC	NC

^aCompared with untreated controls.

I, increased; D, decreased; NC, no change; N/A, not applicable.