Table 1. The signaling pathways significantly down or up-regulated in 12h, 24h and 48h during somitogenesis.

Signaling pathway	Functional class	12h	24h	48h
p53 signaling pathway	Cell growth and death	↑	↑	↓
GnRH signaling pathway	Endocrine system		↓	↓
Adipocytokine signaling pathway	Endocrine system		↓	↓
PPAR signaling pathway	Endocrine system		↑
Insulin signaling pathway	Endocrine system		↓
Chemokine signaling pathway	Immune system	↑	↓	↓
RIG-I-like receptor signaling pathway	Immune system	↑	↑	↓
T cell receptor signaling pathway	Immune system	↑	↓	↓
Toll-like receptor signaling pathway	Immune system	↑		↓
NOD-like receptor signaling pathway	Immune system	↑		↑
Fc epsilon RI signaling pathway	Immune system	↑
B cell receptor signaling pathway	Immune system			↓
Neurotrophin signaling pathway	Nervous system	↑	↓
VEGF signaling pathway	Signal transduction	↑		↓
Calcium signaling pathway	Signal transduction	↓	↓	↓
Notch signaling pathway	Signal transduction	↓	↓	↑
Hedgehog signaling pathway	Signal transduction	↓	↓	↓
ErbB signaling pathway	Signal transduction	↑	↓
MAPK signaling pathway	Signal transduction	↑	↓	↓
mTOR signaling pathway	Signal transduction		↓	↓
Wnt signaling pathway	Signal transduction		↓	↓
TGF-beta signaling pathway	Signal transduction		↓	↓
Jak-STAT signaling pathway	Signal transduction			↓

Here, all of the signaling pathways at 12h, 24h and 48h during somitogenesis were shown. We compared the signaling pathways with KEGG pathway maps, and obtained the functional classification of these signaling pathways presented in second column. Finally, we performed the down or up-regulated information of each signaling pathways at each time points.