Table 2.
Mean functional connectivity of networks across study cohorts.
| Healthy Controls (HC) | Parkinson disease (PD) patients | T test comparisons (p value)a/b | ||||
|---|---|---|---|---|---|---|
| NETWORK | Off | On | HC vs PD-Off | PD-Off vs PD-On | HC vs PD-On | |
|
| ||||||
| Whole brain | 0.27 ± 0.17 | 0.18 ± 0.12 | 0.29 ± 0.22 | 0.089/0.100 | 0.039/0.051 | 0.813/0.823 |
|
| ||||||
| AUD | 0.29 ± 0.19 | 0.17 ± 0.11 | 0.30 ± 0.24 | 0.028/0.040* | 0.013/0.007* | 0.936/0.934 |
|
| ||||||
| CO | 0.29 ± 0.18 | 0.19 ± 0.13 | 0.29 ± 0.24 | 0.089/0.112 | 0.043/0.062 | 0.916/0.925 |
|
| ||||||
| DA | 0.30 ± 0.18 | 0.20 ± 0.14 | 0.30 ± 0.23 | 0.105/0.104 | 0.057/0.057 | 0.950/0.960 |
|
| ||||||
| DMN | 0.23 ± 0.17 | 0.17 ± 0.13 | 0.28 ± 0.24 | 0.272/0.291 | 0.055/0.067 | 0.522/0.543 |
|
| ||||||
| EXE | 0.25 ± 0.20 | 0.18 ± 0.13 | 0.30 ± 0.25 | 0.259/0.276 | 0.063/0.082 | 0.531/0.536 |
|
| ||||||
| SAL | 0.27 ± 0.19 | 0.21 ± 0.14 | 0.29 ± 0.24 | 0.307/0.331 | 0.120/0.141 | 0.749/0.771 |
|
| ||||||
| SOM | 0.30 ± 0.17 | 0.19 ± 0.14 | 0.30 ± 0.23 | 0.050/0.059 | 0.021/0.025* | 0.997/0.994 |
|
| ||||||
| SUB | 0.26 ± 0.20 | 0.19 ± 0.16 | 0.32 ± 0.26 | 0.290/0.308 | 0.045/0.053 | 0.467/0.480 |
|
| ||||||
| VA | 0.29 ± 0.20 | 0.21 ± 0.14 | 0.29 ± 0.27 | 0.204/0.266 | 0.198/0.230 | 0.993/0.993 |
|
| ||||||
| VIS | 0.30 ± 0.18 | 0.16 ± 0.11 | 0.25 ± 0.20 | 0.007/0.010* | 0.120/0.121 | 0.424/0.430 |
Values under participant headings are mean ± s.d. of correlation coefficients measured across nodes constituting each intrinsic brain network. Network abbreviations: AUD = Auditory; CO = Cingulo-Opercular; DA = Dorsal Attention; DFM = Default Mode; EXE = Executive; SAL = Salience; SOM = Sensorimotor; SUB = Subcortical; VA = Ventral Attention; VIS = Visual. Comparison tested with two-tailed independent and paired t-tests,a and checked for reliability using bootstrap resampling with 1,000 samples.b
*
Significant difference of p ≤ 0.05.