Table 3.
Integrated local efficiency for intrinsic networks across study cohorts.
| Healthy Controls (HC) | Parkinson disease (PD) patients | T test comparisons (p value)a/b | ||||
|---|---|---|---|---|---|---|
| NETWORK | Off | On | HCvs PD-Off | PD-Off vs PD-On | HCvs PD-On | |
|
| ||||||
| Whole brain | 0.319 ± 0.007 | 0.323 ± 0.006 | 0.316 ± 0.009 | 0.079/0.077 | 0.039/0.039* | 0.263/0.264 |
|
| ||||||
| AUD | 0.326 ± 0.016 | 0.317 ± 0.023 | 0.312 ± 0.031 | 0.231/0.231 | 0.662/0.667 | 0.125/0.147 |
|
| ||||||
| CO | 0.320 ± 0.019 | 0.323 ± 0.018 | 0.308 ± 0.021 | 0.670/0.678 | 0.184/0.197 | 0.118/0.119 |
|
| ||||||
| DA | 0.320 ± 0.017 | 0.324 ± 0.019 | 0.303 ± 0.013 | 0.575/0.555 | 0.011/0.016* | 0.052/0.058 |
|
| ||||||
| DMN | 0.310 ± 0.021 | 0.320 ± 0.011 | 0.317 ± 0.009 | 0.067/0.039 | 0.287/0.306 | 0.231/0.262 |
|
| ||||||
| EXE | 0.317 ± 0.014 | 0.329 ± 0.010 | 0.318 ± 0.019 | 0.006/0.007* | 0.048/0.062 | 0.831/0.844 |
|
| ||||||
| SAL | 0.313 ± 0.017 | 0.326 ± 0.013 | 0.321 ± 0.017 | 0.018/0.019* | 0.439/0.469 | 0.204/0.217 |
|
| ||||||
| SOM | 0.327 ± 0.011 | 0.327 ± 0.009 | 0.318 ± 0.015 | 0.909/0.914 | 0.087/0.097 | 0.039/0.041* |
|
| ||||||
| SUB | 0.315 ± 0.017 | 0.324 ± 0.014 | 0.335 ± 0.021 | 0.100/0.114 | 0.199/0.205 | 0.007/0.008* |
|
| ||||||
| VA | 0.321 ± 0.013 | 0.317 ± 0.019 | 0.321 ± 0.031 | 0.451/0.416 | 0.393/0.395 | 0.994/0.995 |
|
| ||||||
| VIS | 0.327 ± 0.011 | 0.319 ± 0.017 | 0.306 ± 0.044 | 0.098/0.105 | 0.289/0.285 | 0.064/0.108 |
Values under participant headings are mean ± s.d. of integrated local efficiency measured across nodes constituting each intrinsic brain network. Network abbreviations: AUD = Auditory; CO = Cingulo-Opercular; DA = Dorsal Attention; DMN = Default Mode; EXE = Executive; SAL = Salience; SOM = Sensorimotor; SUB = Subcortical; VA = Ventral Attention; VIS = Visual. Comparison tested with two-tailed independent and paired t-tests,a and checked for reliability using bootstrap resampling with 1,000 samples.b
*
Significance difference of p ≤ 0.05.