Figure 3.

Comparison of mutation profiles between paired tumor samples from individual patients. A, Recurrent bladder tumors share a majority of mutations with pre-radiation primary bladder tumors. B, Metastatic lesions also share alterations with bladder primaries, albeit with less overlap. Variant frequencies for mutations are normalized within each tumor to give relative values, as depicted on the color scales, which allow comparison across a patient's samples. Gene alterations are ordered for each patient based upon relative variant frequency in the reference bladder tumor in the first row of each diagram. For genes with multiple mutations, each shared alteration is represented separately; specific alterations corresponding to the genes listed are given in Supplementary Tables 5-6. Alterations were counted if present at ≥2% frequency.