Table 1.
GOCHA | ISGC ICH Study | GERFHS | ||||
---|---|---|---|---|---|---|
Variable | Cases | Controls | Cases | Controls | Cases | Controls |
No. | 371 | 389 | 404 | 530 | 374 | 319 |
Age, mean (SD) | 74 (10) | 72 (8) | 70 (13) | 66 (16) | 67 (15) | 67 (14) |
Female, No. [%] | 172 [46] | 195 [50] | 189 [47] | 266 [50] | 194 [52] | 172 [54] |
HTN, No. [%] | 274 [75] | 227 [58] | 278 [69] | 247 [47] | 241 [64] | 166 [52] |
T2D, No. [%] | 68 [18] | 35 [9] | 89 [22] | 68 [13] | 72 [19] | 42 [13] |
HL, No. [%] | 144 [39] | 195 [50] | 87 [22] | 48 [9] | 131 [35] | 133 [42] |
Smoking, No. [%] | 56 [15] | 15 [4] | 58 [14] | 74 [14] | 79 [21] | 46 [14] |
Genotyping platform | Illumina 610 | Illumina 610 | Illumina 610 | Illumina 610 | Affymetrix 6.0 | Affymetrix 6.0 |
Lobar,a No. [%] | 205 [55] | – | 135 [33] | – | 156 [42] | – |
Discovery totals: 2,387 individuals (1,149 cases, 1,238 controls), 43% lobar ICH.
Lobar ICH location.
GERFHS = Genetic and Environmental Risk Factors for Hemorrhagic Stroke study; GOCHA = Genes and Outcomes of Cerebral Hemorrhage on Anticoagulation study; HL = hyperlipidemia; HTN = hypertension; ICH = intracerebral hemorrhage; ISGC = International Stroke Genetics Consortium; SD = standard deviation; T2D = type 2 diabetes mellitus.