Table 2.
Replication Populations
| MGH | ERICH | University of Brescia | UMC Utrecht | University of Edinburgh | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Variable | Cases | Controls | Cases | Controls | Cases | Controls | Cases | Controls | Cases | Controls |
| No. | 240 | 458 | 920 | 826 | 198 | 185 | 157 | 160 | 110 | 216 |
| Age, No. (SD) | 76 (10) | 69 (11) | 69 (14) | 68 (13) | 69 (13) | 63 (14) | 62 (13) | 56 (11) | 75 (9) | 76 (10) |
| Female, No. [%] | 96 [40] | 206 [45] | 397 [43] | 371 [45] | 81 [41] | 85 [46] | 66 [42] | 67 [42] | 59 [54] | 118 [54] |
| Lobar, No. [%] | 120 [48] | – | 380 [41] | – | 82 [41] | – | 60 [38] | – | 61 [55] | – |
| Genotyping platform | iPLEX | iPLEX | Taqman | Taqman | iPLEX | iPLEX | iPLEX | iPLEX | iPLEX | iPLEX |
Replication totals: 3,470 individuals (1,625 cases, 1,845 controls), 42% lobar ICH. Discovery + replication totals: 5,625 individuals (2,595 cases, 3,030 controls), 45% lobar ICH.
ERICH = Ethnic/Racial Variations of Intracerebral Hemorrhage; ICH = intracerebral hemorrhage; iPLEX = Sequenom MassARRAY iPLEX Platform; MGH = Massachusetts General Hospital; SD = standard deviation; TaqMan = Applied Biosystems Taqman Genotyping Assay; UMC = University Medical Center.