Table 2.
Clinicopathologic characteristics of high risk human papillomavirus (HR-HPV)-negative and positive squamous cell carcinoma in the parotid gland a.
| Overall | HR-HPV (-) | HR-HPV (+) | ||
|---|---|---|---|---|
| N | 8 | 5 | 3 | |
| Clinical characteristics | ||||
| Age, median ( range) | 68 (51-87) | 67(51 – 87) | 70 (58 – 81) | |
| Gender | ||||
| Male | 7 | 5 | 2 | |
| Female | 1 | 0 | 1 | |
| Smoking status | ||||
| Non-smoker | 5 | 3 | 2 | |
| Ex-Smoker | 3 | 2 | 1 | |
| Clinical staging | ||||
| II | 4 | 4 | 0 | |
| III | 1 | 1 | 0 | |
| IVa | 3 | 0 | 3 | |
| Follow-up period (months)a | 61 (8 – 150) | 78 (21 – 150) | 31 (8 – 69) | |
| Disease status at last F/U | ||||
| No evidence of disease | 7 | 5 | 2 | |
| Dead of disease | 1 | 0 | 1 | |
| Pathological characteristics | ||||
| Tumor Size (cm) | 3.7 (2.1 – 5.0) | 3.1 (2.1 – 4.5) | 4.7 (2.0 – 6.0) | |
| Mitotic index (/10 HPFs) | 12 (2 – 38) | 11 (2 – 38) | 13 (9 – 19) | |
| Surgical Margin Status | ||||
| Negative | 4 | 3 | 1 | |
| Close (<0.1 cm) | 1 | 1 | 0 | |
| Positive | 3 | 1 | 2 | |
| Lymphovascular invasion | ||||
| Yes | 4 | 1 | 3 | |
| No | 4 | 4 | 0 | |
| Perineural invasion | ||||
| Yes | 5 | 2 | 3 | |
| No | 3 | 3 | 0 | |
| Tumor necrosis | ||||
| Yes | 5 | 2 | 3 | |
| No | 3 | 3 | 0 | |
| AJCC pT stage | ||||
| T2 | 4 | 3 | 1 | |
| T3 | 3 | 2 | 1 | |
| T4a | 1 | 0 | 1 | |
| AJCC pN stage | ||||
| N0 | 5 | 5 | 0 | |
| N2b | 3 | 0 | 3 | |
| PIK3CA E545K mutation | ||||
| Yes | 1 | 0 | 1 | |
| No | 7 | 5 | 2 | |
| Loss of PTEN immunoexpression and PTEN deletion on FISH analysis |
||||
| Yes | 1 | 0 | 1 | |
| No | 7 | 5 | 2 | |
a
Values were expressed as N or mean (range).
AJCC: American Joint Committee on Cancer, FISH: fluorescence in situ hybridization, F/U: clinical follow-up, HPFs: high power fields (400X), HPV: human papilloma virus.