Table 1.
Population Characteristics
| Open Cohort* | Closed Cohort | |
|---|---|---|
|
| ||
| Number of women | 1,065,273 | 210,557 |
| Median Age at First Visit (IQR) | 44 (35–53) | 46 (37–55) |
| Median Number of Visits (IQR) | 2 (1–3) | 3 (2–4) |
| Enrollment hc2 Positivity (%) | 5.9% | 5.1% |
| Enrollment Cytology | ||
| Normal | 1,008,658 (95.4) | 202,511 (96.2) |
| Abnormal | 48358 (4.6) | 8066 (3.8) |
| Enrollment Cotest Results# | ||
| Normal Cytology/HPV Negative | 971954 (92.0) | 194727 (92.5) |
| Abnormal Cytology/HPV Negative | 22976 (2.2) | 5176 (2.5) |
| Normal Cytology/HPV Positive | 36704 (3.5) | 7784 (3.7) |
| Abnormal Cytology/HPV Positive | 25382 (2.4) | 2870 (1.4) |
| Enrollment Histology | ||
| Normal | 11740 (41.1) | 3117 (59.9) |
| Atypical squamous | 1274 (4.5) | 295 (5.7) |
| Atypical glandular | 28 (0.1) | 21 (0.4) |
| CIN1 | 10539 (36.9) | 1073 (20.6) |
| CIN2 | 2581(9.0) | 298 (7.6) |
| CIN3/AIS | 2074 (8.3) | 259 (5.0) |
| Cervical cancer, histology unknown | 37 (0.1) | 6 (0.1) |
| Adenocarcinoma | 72 (0.3) | 11 (0.2) |
| Squamous Cell Carcinoma | 204 (0.7) | 25 (0.5) |
| Adenosquamous Carcinoma | 9 (0.0) | 2 (0.0) |
*
Open cohort includes all women cotested at KPNC between 2003 and 2012
Closed cohort (long-term screening cohort) includes only women who were cotested at KPNC in 2003/2004; lack of influx of new patients permitted examination of repeated cotests
#
Abnormal cytology includes ASCUS and higher