Table 4.
Quantitative analysis for eyes with and without macular edema in Groups 1 and 2 combined.
| OCTA Layer | Group No. & OCTA Variable | Eyes without Macular Edema | Eyes with Macular Edema | β (95% CI) | P value |
|---|---|---|---|---|---|
| SRL | SD | 0.088 ± 0.007 | 0.083 ± 0.010 | -0.003 (-0.006, 0.001) | 0.39 |
| VD | 0.392 ± 0.034 | 0.367 ± 0.044 | -0.015 (-0.031, 0.002) | 0.12 | |
| FD | 1.695 ± 0.015 | 1.685 ± 0.025 | -0.006 (-0.015, 0.003) | 0.41 | |
| VDI | 4.462 ± 0.133 | 4.406 ± 0.112 | -0.044 (-0.103, 0.016) | 0.45 | |
|
| |||||
| DRL | SD* | 0.100 ± 0.005 | 0.099 ± 0.004 | -0.002 (-0.004, 0.001) | 0.032 |
| VD* | 0.424 ± 0.008 | 0.416 ± 0.011 | -0.008 (-0.013, -0.003) | < 0.001 | |
| FD | 1.719 ± 0.010 | 1.719 ± 0.009 | -0.002 (-0.006, 0.002) | 0.40 | |
| VDI | 4.263 ± 0.165 | 4.224 ± 0.104 | -0.015 (-0.083, 0.053) | 0.62 | |
|
| |||||
| NS-RL | SD | 0.091 ± 0.011 | 0.091 ± 0.009 | 0.0002 (-0.004, 0.005) | 0.79 |
| VD | 0.391 ± 0.048 | 0.384 ± 0.037 | -0.001 (-0.019, 0.017) | 0.68 | |
| FD | 1.698 ± 0.024 | 1.700 ± 0.019 | 0.002 (-0.008, 0.012) | 0.82 | |
| VDI | 4.285 ± 0.124 | 4.245 ± 0.102 | -0.020 (-0.075, 0.035) | 0.84 | |
OCTA = optical coherence tomography angiography; SRL = superficial retinal layer; DRL = deep retinal layer; NS-RL = non-segmented retinal layer; SD = skeleton density; VD = vessel density; FD = fractal dimension; VDI = vessel diameter index.
Results from both groups combined are shown, including 14 eyes with no ME (n = 12) and 16 eyes with ME (n = 11) from Group 1, and 16 eyes with no ME (n = 12) and 9 eyes with ME (n = 8) from Group 2 (Supplemental Material at AJO.com). The mean and standard deviation are reported for each set of scans in each retinal layer. The beta (β) represents the change in OCTA measurement value per unit increase as one transitions from uveitic eyes without macular edema (ME) to uveitic eyes with ME within that group (corresponding to each row). The 95% confidence intervals (CI) and P values for each comparison are also shown for each row. Parametric analyses were used to estimate β and confidence intervals. Due to concerns of small sample size, nonparametric analysis was performed to evaluate the statistical significance of comparisons. Asterisks indicate metrics with significant differences between uveitic eyes with and without ME from that group.