Table 3.
Linear slope (standard error) estimates for imaging variables that showed a group by time interaction.
| Negative | Low | Medium | High | Chi-squarea | p value | Rankb | |
|---|---|---|---|---|---|---|---|
| Mean Diffusivity | |||||||
| Superior Fronto-Occipital Fasciculus | 0.003 (0.002) | 0.001 (0.002) | 0.006 (0.002) | 0.009 (0.002) | 9.39 | 0.0246 | 6 |
| Brain Volumes | |||||||
| Caudate | −0.003 (0.002) | −0.006 (0.002) | −0.008 (0.002) | −0.014 (0.002) | 23.53 | 3.14E-05 | 1 |
| Putamen | −0.002 (0.002) | −0.0033 (0.003) | −0.008 (0.002) | −0.011 (0.002) | 17.43 | 0.0006 | 2 |
| Corpus callosum | −0.001 (0.001) | −0.003 (0.001) | −0.002 (0.001) | −0.004 (0.001) | 15.09 | 0.0017 | 4 |
| Cortical white matter | −0.064 (0.052) | −0.157 (0.072) | −0.067 (0.052) | −0.323 (0.066) | 14.92 | 0.0019 | 5 |
| Cerebrospinal fluid | 0.0001(0.001) | 0.0005 (0.001) | 0.001 (0.001) | 0.002 (0.001) | 7.82 | 0.0499 | 7 |
| Lateral ventricles | 0.018 (0.010) | 0.031 (0.014) | 0.030 (0.010) | 0.073 (0.012) | 16.55 | 0.0009 | 3 |
a
Chi-square statistics from general linear hypothesis tests for variables showing a significant group by time interaction.
b
Rank-order of interaction effects based on the chi-square statistic. Higher-ranked variables show a greater annualized rate of change amongst the groups.