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. Author manuscript; available in PMC: 2016 Dec 21.
Published in final edited form as: J Antibiot (Tokyo). 2016 May 18;69(12):871–878. doi: 10.1038/ja.2016.44

Figure 1.

Figure 1

Schematic6 of Gram-positive cell wall components (A) and crosslinking of peptidoglycan using PBPs 1 and 3, which can be inhibited by β-lactams (B), and PBP2a, which cannot (C). PBP2a requires WTA to be properly localized; BPEI can bind to WTA to prevent PBP2a from functioning properly (D).