Table 1.

MIC (µg/ml) of ampicillin-tetramic acid hybrids against gram-positive bacteria.

Compound	EF	SPy	SP	BA	BS	MSSA	MRSA
ampicillin	3.13	<0.2	<0.2	<0.2	<0.2	<0.2	50
piperacillin	3.13	<0.2	<0.2	0.39	0.39	<0.2	25
carbenicillin	3.13	<0.2	<0.2	<0.2	<0.2	<0.2	6.25
1903	25	0.39	0.39	3.13	1.56	0.78	25
1905	50	0.78	<0.2	3.13	3.13	0.78	50
1940	25	0.78	0.78	3.13	3.13	1.56	25
2742	25	1.56	1.56	6.25	3.13	1.56	100
2743	12.5	<0.2	<0.2	0.78	0.78	0.78	25
2744	12.5	0.78	0.39	6.25	3.13	1.56	25
2745	12.5	0.78	0.39	6.25	3.13	0.78	25
2746	25	0.39	0.39	1.56	3.13	1.56	50
2780	25	0.78	0.39	1.56	0.78	0.39	50
2781	25	0.39	<0.2	3.13	0.78	<0.2	25
2782	6.25	0.78	0.39	3.13	1.56	0.39	12.5
2833	12.5	0.78	<0.2	1.56	0.39	<0.2	25
2835	25	0.78	<0.2	3.13	<0.2	<0.2	25
2916	25	0.39	<0.2	1.56	1.56	<0.2	50
2917	25	0.39	<0.2	3.13	1.56	0.78	50
2918	25	1.56	0.39	6.25	3.13	0.78	50
2919	25	0.78	<0.2	3.13	1.56	0.78	50
3002	25	0.39	0.39	3.13	1.56	0.78	50

Key: EF= E. faecalis ATCC33186; SPy= S. pyogenes ATCC700294; SP= S. pneumoniae R6; BA= B. anthracis sterne; BS= B. subtilis ATCC23857; MSSA= S. aureus -ATCC29213; MRSA= S. aureus NRS 70.