Table 2.
MIC (µg/ml) of ampicillin-tetramic acid hybrids against gram-negative bacteria.
| Compound | AB | EC | ECΔtolC | PV | PM | KP | PA |
|---|---|---|---|---|---|---|---|
| ampicillin | 100 | 3.13 | 3.13 | 100 | 3.13 | 100 | >200 |
| piperacillin | 6.25 | 6.25 | 1.56 | 1.56 | 0.19 | 6.25 | 6.25 |
| carbenicillin | 100 | 100 | 0.09 | 100 | 1.56 | 50 | 100 |
| 1903 | 50 | 50 | 6.25 | 25 | 12.5 | 200 | 12.5 |
| 1905 | 200 | 25 | 6.25 | 50 | 25 | 200 | 25 |
| 1940 | 100 | 50 | 12.5 | 50 | 6.25 | >200 | 25 |
| 2742 | 100 | 100 | 12.5 | 100 | 6.25 | >200 | 25 |
| 2743 | 50 | 200 | 12.5 | 100 | 3.13 | >200 | 25 |
| 2744 | 100 | 100 | 3.13 | 12.5 | 12.5 | >200 | 25 |
| 2745 | 50 | 100 | 3.13 | 12.5 | 3.13 | >200 | 25 |
| 2746 | 200 | 200 | 12.5 | 100 | 3.13 | >200 | 50 |
| 2780 | >200 | 200 | 6.25 | 12.5 | 1.56 | >200 | 25 |
| 2781 | 50 | 100 | 3.13 | 6.25 | 3.13 | >200 | 12.5 |
| 2782 | 25 | 25 | 1.56 | 12.5 | 12.5 | >200 | 25 |
| 2833 | 25 | 100 | 3.13 | 100 | 6.25 | 200 | 25 |
| 2835 | 50 | 100 | 3.13 | 25 | 25 | 200 | 25 |
| 2916 | 50 | 50 | 1.56 | 6.25 | 6.25 | >200 | 25 |
| 2917 | 50 | 12.5 | 6.25 | 6.25 | 3.1 | >200 | 25 |
| 2918 | 100 | 6.25 | 6.25 | 6.25 | 6.25 | >200 | 50 |
| 2919 | 25 | 12.5 | 3.13 | 25 | 50 | 200 | 50 |
| 3002 | 50 | 6.25 | 3.13 | 25 | 1.56 | 200 | 12.5 |
Key: AB= A. baumannii ATCC 19606; EC= E. coli BW25113; ECΔtolC= E. coli BW25113 ΔtolC derivative JW5503-1; PV= P. vulgaris ATCC 33420; PM= P. mirabilis ATCC 25933; KP= K. pneumoniae ATCC 13883; PA= P. aeruginosa PA01.