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. Author manuscript; available in PMC: 2018 Jun 15.
Published in final edited form as: Dev Biol. 2016 May 18;426(2):429–441. doi: 10.1016/j.ydbio.2016.05.014

Figure 4. The ECM protein EFEMP2 inhibits activin signaling downstream of the activated receptor.

Figure 4

A) The ECM protein EFEMP2, but not SPARC, inhibited activin-induced mesodermal formation in animal caps. B) EFEMP2 interfered with mesodermal induction by both activin and the activated type I activin receptor ALK4 (CA-ALK4), but did not inhibit mesodermal induction by Smad2 or Smad2-induced animal cap elongation. The doses of RNA used: activin, 2pg; CA-ALK4, 1ng; Smad2, 1ng; EFEMP2, 1ng.