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. 2016 Nov 17;145(19):194103. doi: 10.1063/1.4967809

FIG. 1.

FIG. 1.

The flow chart shows various options for the MSM construction starting from raw trajectory data. The state decomposition occurs in the clustering step, which is a requisite step in every MSM building protocol. The options presented in each box are intended to be a representative but not exhaustive set.