Table 1.
Effects of fructans on weight gain, body fat, lipid profile and liver enzymes in mice fed a HFD for eight weeks
| Obese | Treatments | ||||
|---|---|---|---|---|---|
| Linear chicory fructans | Branched Agave fructans | ||||
| Unfractionated | Fractionated | ||||
| HFD | HFD + OS1 | HFD + F | HFD + LcF | HFD + ScF | |
| Final body weight (g) | 36.71 ± 1.5 | 36.55 ± 3.6 | 35.52 ± 3.7 | 37.49 ± 4.2 | 33.5 ± 2.2* |
| Gain weight (g) | 16.37 ± 2.0 | 13.26 ± 1.0 | 12.54 ± 0.82 | 11.92 ± 1.2 | 8.96 ± 0.42* |
| Fat Mass (g) | 4.32 ± 0.25 | 3.82 ± 0.62 | 4.48 ± 0.37 | 4.20 ± 0.42 | 2.28 ± 0.52* |
| Epididymal (g) | 1.86 ± 0.10 | 1.68 ± 0.30 | 1.85 ± 0.14 | 2.04 ± 0.21 | 1.04 ± 0.15* |
| Visceral (g) | 0.67 ± 0.03 | 0.62 ± 0.09 | 0.51 ± 0.05 | 0.65 ± 0.06 | 0.42 ± 0.11 |
| Subcutaneous (g) | 1.78 ± 0.18 | 1.50 ± 0.25 | 1.19 ± 0.11 | 1.50 ± 0.15 | 0.71 ± 0.19* |
| Triglycerides (mg/dl) | 196.0 ± 60.4 | 136.6 ± 8.8 | 95.0 ± 5.5* | 92.6 ± 5.2* | 129.6 ± 9.8 |
| Total cholesterol (mg/dl) | 147.6 ± 8.5 | 140.0 ± 13.0 | 151.3 ± 2.1 | 145.6 ± 5.2 | 124.3 ± 3.1 |
| HDL (mg/dl) | 71.3 ± 10.9 | 80.0 ± 5.0 | 79.3 ± 4.0 | 70.6 ± 8.7 | 55.3 ± 8.5 |
| LDL (mg/dl) | 37.0 ± 10.6 | 32.67 ± 10.4 | 53.0 ± 2.6 | 56.3 ± 14.1 | 43.3 ± 9.3 |
| VLDL (mg/dl) | 39.3 ± 11.9 | 27.3 ± 1.6 | 19.0 ± 1.1 | 18.6 ± 0.8 | 25.6 ± 2.0 |
| Glucose (mg/dl) | 171.0 ± 17.1 | 139.1 ± 19.5* | 137.1 ± 14.11* | 160.4 ± 20.5 | 129.1 ± 22.4* |
| AST (U/l) | 159.0 ± 9.6 | 134.6 ± 22.5 | 146.6 ± 28.3 | 101.6 ± 21.2 | 66.3 ± 8.5* |
| ALT (U/l) | 64.6 ± 9.6 | 51.3 ± 11.6 | 46.3 ± 4.4 | 52.3 ± 1.4 | 47.0 ± 2.3 |
Mean ± SD, growth parameters n = 10, biochemical parameters n = 6. * p < 0.05
Abbreviations: ALT alanine aminotransferase, AST aspartate aminotransferase, F total fructans, HFD high-fat diet, HDL high-density lipoproteins, LcF fructans with higher dp, LDL low-density lipoproteins, OS1 Orafti sinergy1, ScF fructans with lower dp, SD standard-diet, VLDL very low-density lipoproteins