Table 1. Correlation between the clinicopathological features and SENP3 expression.

Characteristics	Case no.	Positivity area of SENP3 (%)	Non-parametric test value	P-value
Gender
Male	152	28.24±14.29	Z=−0.604	0.546
Female	7	30.05±15.64
Tobacco smoking*
Yes	117	29.81±14.41	Z=−2.237	0.025
No	42	24.15±13.29
Alcohol
Yes	25	33.35±14.87	Z=−1.874	0.061
No	134	27.38±14.05
Nodal status**
N0	111	26.37±14.15	Z=−2.735	0.006
N1-2	48	32.83±13.74
Pathological differentiation grade
Well	67	26.37±14.15	X2=2.626 d.f.=2	0.269
Moderate	82	32.83±13.74
Poor	10	26.37±14.15
Clinical stage (TNM classification)**
I	52	24.56±13.53	X2=15.789 d.f.=3	0.001
II	39	23.86±9.375
III	43	32.07±15.74
IV	25	36.64±14.96
Tumor stage*
T1	52	24.56±13.53	X2=10.407 d.f.=3	0.015
T2	52	26.64±11.74
T3	37	31.41±15.42
T4	18	37.66±16.40
Tumor site
Supraglottic	50	29.28±11.68	X2=0.452 d.f.=2	0.798
Glottic	91	28.44±16.52
Subglottic	18	27.80±10.94

Abbreviations: d.f., degree of freedom; TNM, tumor, lymph node, metastasis. **P<0.01, *P<0.05.