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. Author manuscript; available in PMC: 2016 Dec 5.
Published in final edited form as: Mol Psychiatry. 2013 Feb 12;19(3):358–367. doi: 10.1038/mp.2013.3

Fig. 3. Bilateral partial 6-OHDA lesions of the SNc, but not of the mVTA, decrease consummatory responses, weight gain and social interaction without affecting olfaction.

Fig. 3

(A, B) Water (A) and food (B) intake in the homecage were measured over a 24-hour period. (B) Both lesions resulted in a loss of weight after surgery, but mVTA-lesioned animals recovered during the three weeks following surgery, whereas SNc-lesioned animals continued to gain less weight than the controls (Effects of lesion: Fs > 4.48, Ps < 0.05 and significant lesion x day interaction: Fs > 5.16, Ps < 0.001). (D) SNc lesions reduced the time spent in social interaction with a congener. (E, F) 6-OHDA lesions did not affect attraction toward an appetitive (coconut, E) or avoidance from an aversive (acetic acid, F) odor n = 12–18. *P < 0.05, **P < 0.01, ***P < 0.001, Sham-operated vs. Lesioned.