Fig. 4.

Over-represented protein pathways depend on vesicle type. (a) Venn diagrams of detected proteins in exosomes and microvesicles of 3 different source cell types. MSC EVs had a lower diversity of proteins. (b) Proteins shared among exosomes or microvesicles derived from all 3 source cell types (middle section in the Venn diagrams) underwent gene ontology analysis. The negative logarithm of p-values is shown for each GO term, colourful lines represent significance threshold (p=0.05). Common (depicted in black), as well as distinct (depicted in colour) pathways emerged in exosomes versus microvesicles.