Table 2. Genes with the strongest frequency changes in the PRH Ancient individuals.

Gene	PBS	P value	Sites	Description
HLA–DQA1	0.275500845	0.01675	17	Major histocompatibility complex, class II, DQ alpha 1
CELA3A	0.194966437	0.03102	29	Basic leucine zipper nuclear factor 1

PBS, population branch statistic; PRH, Prince Rupert Harbour. P values were calculated using neutral simulations. See ‘Methods' section.