Table 2.
Main characteristics of studies and animal models of the papers included for expression in the tendon injury or overuse model tissues search
| Author | Year | Journal | Tendon | Model | Healthy control? | Quantitative/semiquantitative analysis and statistical tests | Investigated genes and proteins |
|---|---|---|---|---|---|---|---|
| TGF-β | |||||||
| Zhang et al. [47] | 2016 | Matrix Biol | Achilles, mouse | Transection | Yes | Yes | TGFβ1, TGFβ2, TGFβ3, TGFβR1, TGFβR2 |
| Gao et al. [30] | 2013 | PLoS One | FD, rat | Overuse | Yes | Yes | TGFβ1 |
| Heisterbach et al. [48] | 2012 | Knee Surg Sports Traumatol Arthrosc | Achilles, rat | Transection → repair | Yes | Yes | TGFβ1 |
| Otoshi et al. [49] | 2011 | Arthroscopy | Achilles, rat | Removal | Yes | Yes | TGFβ1 |
| Lin et al. [50] | 2010 | Bone | Achilles, rat | Transection | Yes | Yes | TGFβ1, TGFβ2, TGFβ3 |
| Chen et al. [51] | 2008 | J Hand Surg Am | FDP, chicken | Transection → repair | Yes | Yes | TGFβ |
| Chan et al. [52] | 2008 | Wound Repair Regen | Patella, rat | Defect | Yes | Yes | TGFβ1, TGFβ2, TGFβ3, TGFβR1, TGFβR2 |
| Würgler-Hauri et al. [53] | 2007 | J Shoulder Elbow Surg | RC, rat | Detach → repair | Yes | No | TGFβ1 |
| Berglund et al. [54] | 2006 | J Hand Surg Am | FDP, rabbit | Division → repair | Yes | Yes | TGFβ1 |
| Kobayashi et al. [55] | 2006 | J Shoulder Elbow Surg | RC, rabbit | Defect | Yes | No | TGFβ |
| Galatz et al. [56] | 2006 | J Orthop Res | RC, rat | Transection → repair | Yes | Yes | TGFβ1, TGFβ3 |
| Dahlgren et al. [57] | 2005 | J Orthop Res | FDS, horse | CI | Yes | No | TGFβ1 |
| Darmani et al. [58] | 2004 | Mediators Inflamm | FD, rat | Crush injury | Yes | No | TGFβ |
| Ngo et al. [59] | 2001 | Plast Reconstr Surg | FDP, rabbit | Transection → repair | Yes | No | TGFβR1, TGFβR2, TGFβR3 |
| Chang et al. [60] | 1997 | Plast Reconstr Surg | FDP, rabbit | Transection → repair | Yes | Yes | TGFβ1 |
| Natsu-ume et al. [61] | 1997 | J Orthop Res | Patella, rat | Transection | Yes | Yes | TGFβ |
| BMPs | |||||||
| Zhang et al. [47] | 2016 | Matrix Biol | Achilles, mouse | Transection | Yes | Yes | BMP1– BMP7, BMP12– BMP14, BMPR1, BMPR2 |
| Heisterbach et al. [48] | 2012 | Knee Surg Sports Traumatol Arthrosc | Achilles, rat | Transection → repair | Yes | Yes | BMP12 |
| Yee Lui et al. [62] | 2011 | J Orthop Res | Patella, rat | CI | Yes | Yes | BMP2, BMP4, BMP7 |
| Lin et al. [50] | 2010 | Bone | Achilles, rat | Transection | Yes | Yes | BMP2, BMP4, BMP7 |
| Lui et al. [63] | 2009 | J Orthop Surg Res | Patella, rat | CI/defect | Yes | Yes | BMP2 |
| Eliasson et al. [64] | 2008 | Clin Orthop Relat Res | Achilles, rat | Transection | Yes | Yes | BMP7, BMP12, BMP13, BMP14, BMPR |
| Würgler-Hauri et al. [53] | 2007 | J Shoulder Elbow Surg | RC, rat | Detach → repair | Yes | No | BMP12, BMP13, BMP14 |
| CTGF | |||||||
| Gao et al. [30] | 2013 | PLoS One | FD, rat | Overuse | Yes | Yes | CTGF |
| Kietrys et al. [31] | 2012 | PLoS One | FD, rat | Overuse | Yes | Yes | CTGF |
| Fedorczyk et al. [32] | 2010 | J Orthop Res | FD, rat | Overuse | Yes | Yes | CTGF |
| Chen et al. [51] | 2008 | J Hand Surg Am | FDP, chicken | Transection | Yes | Yes | CTGF |
| Asundi et al. [42] | 2008 | Eur J Appl Physiol | FDP, rabbit | Overuse | Yes | Yes | CTGF |
| Würgler-Hauri et al. [53] | 2007 | J Shoulder Elbow Surg | RC, rat | Detach → repair | Yes | No | CTGF |
| Berglund et al. [54] | 2006 | J Hand Surg Am | FDP, rabbit | Division → repair | Yes | Yes | CTGF |
| Nakama et al. [43] | 2006 | J Orthop Res | FDP, rabbit | Overuse | Yes | Yes | CTGF |
BMP bone morphogenic protein, CI collagenase-induced, CTGF connective tissue growth factor, FD flexor digitorum, FDP flexor digitorum profundus, FDS flexor digitorum superficialis, RC rotator cuff, TGF-β transforming growth factor beta