Table 4.
Multivariable logistic regression analysis of risk factors for hematological adverse events
| Variables | Grade 0–2 (N = 196) |
Grade 3–4 (N = 38) |
Univariate | Multivariate a) | |||
|---|---|---|---|---|---|---|---|
| OR (95% CI) | p | OR (95% CI) | p | ||||
| Age (y) | 0.99 (0.96–1.02) | 0.472 | |||||
| Sex | Female | 66 (75.9%) | 21 (24.1%) | 2.43 (1.20–4.92) | 0.013 | 2.39 (1.15–4.96) | 0.020 |
| Male | 130 (88.4%) | 17 (11.6%) | 1.00 | 1.00 | |||
| Operation type | Total | 72 (77.4%) | 21 (22.6%) | 2.13 (1.05–4.29) | 0.035 | 1.79 (0.86–3.74) | 0.119 |
| Distal | 124 (87.9%) | 17 (12.1%) | 1.00 | 1.00 | |||
| Creatinine clearance (mL/min) b) | ≥60 | 165 (83.8%) | 32 (16.2%) | 1.00 | 0.997 | ||
| <60 | 31 (83.8%) | 6 (16.2%) | 0.99 (0.39–2.59) | ||||
| Albumin (g/dL) | <3.5 | 24 (70.6%) | 10 (29.4%) | 2.56 (1.11–5.92) | 0.028 | 2.45 (1.02–5.89) | 0.045 |
| ≥3.5 | 172 (86.0%) | 28 (14.0%) | 1.00 | 1.00 | |||
| BMI (kg/m2) | 0.83 (0.72–0.95) | 0.007 | 0.86 (0.74–0.99) | 0.035 | |||
| PG-SGA category | A | 78 (81.3%) | 18 (18.8%) | 1.00 | 0.078 | ||
| B | 118 (85.5%) | 20 (14.5%) | 0.44 (0.17–1.09) | ||||
| PG-SGA score | 0.88 (0.76–1.01) | 0.083 | |||||
| Weight loss (%) | 0.97 (0.88–1.07) | 0.558 | |||||
| NRI | 0.96 (0.89–1.02) | 0.163 | |||||
a)Covariates used in multivariate analyses included sex, operation type, albumin, and BMI; b)Creatinine clearance was calculated using the Cockroft–Gault formula; BMI Body Mass Index, PG-SGA Patient-Generated Subjective Global Assessment, NRI Nutritional Risk Index