Table 6.
Multivariable logistic regression analysis of risk factors for neutropenia
| Variables | Grade 0–2 (N = 202) |
Grade 3–4 (N = 32) |
Univariate | Multivariate a) | |||
|---|---|---|---|---|---|---|---|
| OR (95% CI) | p | OR (95% CI) | p | ||||
| Age (y) | 0.99 (0.42–2.33) | 0.554 | |||||
| Sex | F | 70 (80.5%) | 17 (19.5%) | 2.14 (1.01–4.54) | 0.048 | 2.24 (1.03–4.87) | 0.043 |
| M | 132 (89.8%) | 15 (10.2%) | 1.00 | 1.00 | |||
| Operation type | Total | 73 (78.5%) | 20 (21.5%) | 2.95 (1.36–6.37) | 0.006 | 2.71 (1.23–5.97) | 0.013 |
| Distal | 129 (91.5%) | 12 (8.5%) | 1.00 | 1.00 | |||
| Creatinine clearance (mL/min) b) | ≥60 | 170 (86.3%) | 27 (13.7%) | 1.00 | 0.975 | ||
| <60 | 32 (86.5%) | 5 (13.5%) | 0.98 (0.35–2.75) | ||||
| Albumin (g/dL) | <3.5 | 25 (73.5%) | 9 (26.5%) | 2.77 (1.15–6.66) | 0.023 | 2.61 (1.01–6.54) | 0.040 |
| ≥3.5 | 177 (88.5%) | 23 (11.5%) | 1.00 | 1.00 | |||
| BMI (kg/m2) | 0.87 (0.75–1.00) | 0.054 | |||||
| PG-SGA category | A | 80 (83.3%) | 16 (16.7%) | 1.00 | 0.106 | ||
| B | 122 (88.4%) | 16 (11.6%) | 0.44 (0.16–1.19) | ||||
| PG-SGA score | 0.87 (0.75–1.02) | 0.080 | |||||
| Weight loss (%) | 1.11 (0.92–1.12) | 0.728 | |||||
| NRI | 0.95 (0.89–1.01) | 0.110 | |||||
a)Covariates used in multivariate analyses included sex, operation type, and albumin; b)Creatinine clearance was calculated using the Cockroft–Gault formula; BMI Body Mass Index, PG-SGA Patient-Generated Subjective Global Assessment, NRI Nutritional Risk Index