Table 2.
Relationships between TIN density and clinical characteristics in TGCT patients (N = 102)
| TIN density | ||||
|---|---|---|---|---|
| Low (N = 81) | High (N = 21) | P value | ||
| Age (years ± SD)a | 34.7 ± 11.2 | 31.7 ± 12.3 | 0.1438 | |
| Tumor marker | ||||
| LDH (N = 99) | Normal | 41 (42%) | 7 (7%) | 0.1768 |
| High | 38 (38%) | 13 (13%) | ||
| AFP (N = 99) | Normal | 55 (56%) | 12 (12%) | 0.2449 |
| High | 23 (23%) | 9 (9%) | ||
| βhCG (N = 101) | Normal | 31 (31%) | 7 (7%) | 0.6484 |
| High | 49 (48%) | 14 (14%) | ||
| T stage | T1 | 50 (49%) | 8 (8%) | 0.0513 |
| T2-T4 | 31 (30%) | 13 (13%) | ||
| S stage (N = 97) | S0-1 | 58 (60%) | 10 (10%) | 0.0275 |
| S2-3 | 19 (20%) | 10 (10%) | ||
| Stage | Stage I | 65 (64%) | 7 (7%) | <0.0001 |
| Stage II-III | 16 (15%) | 14 (14%) | ||
| IGCCC riskb | Good | 10 (33%) | 8 (27%) | 0.8051 |
| Intermediate | 4 (13%) | 3 (10%) | ||
| Poor | 2 (7%) | 3 (10%) | ||
TIN tumor-infiltrating neutrophil, TGCT testicular germ cell tumor, LDH lactate dehydrogenase, αFP α feto protein, βhCG β human chorionic gonadotropin, IGCCC International Germ Cell Consensus Classification. aWilcoxon rank-sum test was used for statistical analysis in evaluating age between low and high density groups. Pearson’s chi square test was performed for other parameters. bNote that the IGCCC risk classification is applied only in patients with metastatic TGCT patients