Table 1.
Baseline demographic, clinical and laboratory parameters
| All (n=18) | HCV (n=6) | HIV/HCV (n=8) | HIV (n=4) | |
|---|---|---|---|---|
| Age, years (median, range) | 57 (45–65) | 59 (49–63) | 53 (45–61) | 55 (50–65) |
| Male sex, n (%) | 14 (78%) | 3 (50%) | 7 (87%) | 4 (100%) |
| Self-reported Race and Ethnicity, n (%) | ||||
| Black, not Hispanic/Latino | 6 (33%) | 2 (33%) | 4 (50%) | 0 (0%) |
| White, not Hispanic/Latino | 8 (44%) | 4 (67%) | 2 (25%) | 2 (50%) |
| American Indian | 1 (6%) | 0 | 1 (13%) | 0 |
| Hispanic/Latino | 3 (17%) | 0 | 1 (12%) | 2 (50%) |
| Body mass index, kg/m2 (median, range) | 30 (21–46) | 32 (22–45) | 30 (21–46) | 30 (28–32) |
| Alkaline phosphatase, U/L(median, range) | 102 (61–210) | 89 (61–143) | 114 (82–119) | 112 (75–210) |
| Aspartate aminotransferase (AST), U/L (median, range) | 63 (31–151) | 96 (31–151) | 56 (43–96) | 66 (49–116) |
| Alanine aminotransferase (ALT), U/L (median, range) | 84 (37–161) | 106 (46–144) | 58 (37–90) | 98 (67–161) |
| Total bilirubin, mg/dL (median, range) | 0.8 (0.3–2.3) | 0.7 (0.4–1.3) | 0.8 (0.3–2.3) | 0.9 (0.4–1.6) |
| Platelets, K/uL (median, range) | 152 (45–250) | 132 (75–239) | 180 (45–250) | 138 (57–166) |
| Hepatitis C genotype, n (%) | ||||
| 1a | 5 (83%) | 7 (88%) | NA | |
| 1b | 1 (17%) | 1 (12%) | NA | |
| Hepatitis C treatment experienced, n (%) | 4 (66%) | 6 (75%) | NA | |
| HIV viral load, copies/mL (median, range) | NA | <40 (<40–220) | <40 (<40–172) | |
| CD4 count, cells/mm3 (median, range) | 572 (123–2558) | 976 (410–2558) | 572 (173–1049) | 189 (123–260) |
| Hepatic venous portal gradient (HVPG), mmHg (median, range) | 9 (3–15) | 10 (4–12) | 7 (3–15) | 7 (3–15) |
| HVPG≥10mmHg, n (%) | 6 (33%) | 3 (50%) | 2 (25%) | 1 (25%) |
| Liver biopsy | ||||
| Length, mm (median, range) | 14 (5–24) | 13 (6–18) | 13 (5–18) | 15 (9–24) |
| Ishak fibrosis score (median, range) | 5 (3–6) | 6 (3–6) | 4 (3–6) | 5 (3–6) |
| Ishak inflammation score (median, range) | 8 (4–14) | 8 (4–9) | 9 (8–14) | 6 (4–9) |
| Steatosis (median, range) | Trace (0–2) | Trace (0–1) | Trace (0–2) | 2 (Trace–2) |