Table 3.
Univariate and multivariable predictors of time to secondary decompression. Of note, the hazard ratios for preoperative proptosis, ethnicity, and active disease change over time (see results section), and thus only significance of the covariate by time interaction is reported here. Indications for secondary decompression include proptosis (n = 79), exposure keratopathy (n = 74), compressive optic neuropathy (n = 6), and/or other (n = 15). CI = confidence interval. Statistically significant P values are in bold.
| Univariate Analysis* | Multivariable Analysis | ||||||
|---|---|---|---|---|---|---|---|
| Covariate | Hazard Ratio |
95% CI (lower, upper) |
P value | P value† | Hazard Ratio |
95% CI (lower, upper) |
P value |
| Age (per year) | 0.93 | (0.85, 1.02) | 0.3640 | 1.0000 | 0.91 | (0.83, 1.00) | 0.0434 |
| Preoperative proptosis (per mm) | 0.0240 | 0.4560 | 1.20 | (1.10, 1.32) | 0.0001 | ||
| Unilateral operation | |||||||
| Yes | 1.92 | (1.10, 3.45) | 0.0221 | 0.4420 | 2.00 | (1.08, 3.70) | 0.0272 |
| No | Reference | Reference | Reference | Reference | |||
| Steroids | |||||||
| Yes | 1.72 | (0.66, 4.49) | 0.2642 | 1.0000 | 2.48 | (1.15, 5.32) | 0.0200 |
| No | Reference | Reference | Reference | Reference | |||
| Fat decompression | |||||||
| Yes | 0.26 | (0.14, 0.45) | <0.0001 | 0.0025 | 0.32 | (0.17, 0.60) | 0.0004 |
| No | Reference | Reference | Reference | Reference | |||
| Walls decompressed | 0.0021 | 0.0483 | 0.0059 | ||||
| Medial | 1.46 | (0.61, 3.51) | 0.3975 | 1.73 | (0.75, 3.97) | 0.1993 | |
| Lateral | Reference | Reference | Reference | Reference | |||
| Balanced | 0.42 | (0.25, 0.72) | 0.0014 | 0.41 | (0.23, 0.75) | 0.0039 | |
| Ethnicity | 0.0390 | ||||||
| Caucasian | Reference | Reference | Reference | Reference | |||
| African-American | <0.0001 | 0.0025 | 0.33 | (0.15, 0.75) | 0.0076 | ||
| Asian-American | 0.2640 | 1.0000 | 0.72 | (0.09, 5.60) | 0.7536 | ||
| Other | 0.0028 | 0.0616 | 1.81 | (0.31, 10.4) | 0.5084 | ||
| Thyroid disease | 0.0591 | 1.0000 | 0.0347 | ||||
| Hyperthyroid disease | Reference | Reference | Reference | Reference | |||
| None | 2.79 | (1.08, 7.21) | 0.0337 | 2.77 | (1.22, 6.28) | 0.0148 | |
| Hypothyroid disease | 1.94 | (0.67, 5.60) | 0.2206 | 1.62 | (0.65, 4.08) | 0.3033 | |
| Activity | |||||||
| Active | 0.0035 | 0.0735 | |||||
| Inactive | Reference | Reference | |||||
*
Univariate results: only covariates with either adjusted P values < 0.30 on univariate analysis or that became significant on multivariable analysis are shown.
†
P values adjusted for multiple comparisons using the Holm method.