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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Immunol Allergy Clin North Am. 2016 Sep 13;36(4):719–734. doi: 10.1016/j.iac.2016.06.008

Figure 2. Pathway depicting metabolites of arachidonic acid important in AERD.

Figure 2

Following conversion to arachidonic acid by phospholipase A2, further processing occurs via either the prostaglandin pathway mediated by COX-1/COX-2 or the leukotriene pathway mediated by 5-lipoxygenase. Red lettering shows genes inhibited by IL-4 and pink lettering show genes stimulated by IL-4 and IFN-γ.