Table 1.
Effect of the ruthenium complexes on HSkMEC angiogenesis
| Cell treatment | Vessels number (>100 μM) | Vessels mean length (μM) | ||
|---|---|---|---|---|
| % Control | Mean ± SD | % Control | ||
| Normoxia | ||||
| Control | 89 | 100 | 140 ± 67 | 100 |
| [NAMI-A] = 50 μM | 100 | 112 | 125 ± 65 | 89 |
| [NAMI-A] = 100 μM | 103 | 116 | 125 ± 64 | 89 |
| Hypoxia | ||||
| Control | 50 | 100 | 122 ± 69 | 100 |
| [NAMI-A] = 50 μM | 52 | 103 | 110 ± 55 | 90 |
| [NAMI-A] = 100 μM | 55 | 109 | 110 ± 56 | 90 |
| Normoxia | ||||
| Control | 101 | 100 | 136 ± 63 | 100 |
| [Ru-Ind] = 50 μM | 108 | 107 | 115 ± 45 | 84 |
| [Ru-Ind] = 100 μM | 104 | 103 | 86 ± 55 | 63 |
| Hypoxia | ||||
| Control | 79 | 100 | 109 ± 53 | 100 |
| [Ru-Ind] = 50 μM | 63 | 80 | 94 ± 44 | 87 |
| [Ru-Ind] = 100 μM | 35 | 44 | 71 ± 31 | 65 |
| Normoxia | ||||
| Control/0.1 % DMSO | 98 | 100 | 133 ± 65 | 100 |
| [Ru-Isq] = 50 μM | 137 | 139 | 122 ± 58 | 92 |
| [Ru-Isq] = 100 μM | 108 | 110 | 99 ± 44 | 74 |
| Hypoxia | ||||
| Control/0.1 % DMSO | 65 | 100 | 97 ± 43 | 100 |
| [Ru-Isq] = 50 μM | 31 | 48 | 79 ± 47 | 82 |
| [Ru-Isq] = 100 μM | 15 | 24 | 70 ± 25 | 72 |