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. Author manuscript; available in PMC: 2017 Jul 18.
Published in final edited form as: Drug Discov Today Technol. 2016 Jul 18;19:17–22. doi: 10.1016/j.ddtec.2016.05.003

Figure 2.

Figure 2

Phosphorylation-induced contact switch in BRD4 regulated by CK2 and PP2A. PDID represents a phosphorylation-dependent interaction domain that encompasses BD2 and NPS as bracketed in dashed lines. Nuc and TF are abbreviations for nucleosome and transcription factors, respectively, and asterisks indicate the acetyl-lysine (Ac) in nucleosome or transcription factors. Dashed lines connecting BD2 and NPS in the dephosphorylation state as well as circled P between NPS and BID in the phosphorylation state show intra-molecular contacts within BRD4 dictated by the extent of phosphorylation.