Table 2.
Sensitivity analysis showing the effect sizes for the primary outcomes after removing individual trials included in the meta-analysis.
| LVEF | Overall mortality | |||
|---|---|---|---|---|
| MD [95% CI] | P value | RR [95% CI] | P value | |
| All trials | RE: 5.34 [3.85, 6.82] | <0.00001 | RE: 1.00 [0.97, 1.03] | 0.98 |
| FE: 3.89 [3.08, 4.69] | <0.00001 | FE: 1.00 [0.96, 1.04] | 0.95 | |
| Naughton et al. 1995 omitted | RE: 5.24 [3.72, 6.75] | <0.00001 | RE: 1.00 [0.97, 1.03] | 0.98 |
| FE: 3.83 [3.02, 4.64] | <0.00001 | FE: 1.00 [0.96, 1.04] | 0.95 | |
| Granton et al. 1996 omitted | RE: 5.23 [3.73, 6.73] | <0.00001 | RE: 1.00 [0.97, 1.03] | 0.98 |
| FE: 3.84 [3.03, 4.65] | <0.00001 | FE: 1.00 [0.96, 1.04] | 0.95 | |
| Tkacova et al. 1997 omitted | RE: 5.23 [3.72, 6.74] | <0.00001 | RE: 1.00 [0.97, 1.03] | 0.98 |
| FE: 3.83 [3.02, 4.64] | <0.00001 | FE: 1.00 [0.96, 1.04] | 0.95 | |
| Kaneko et al. 2003 | RE: 5.19 [3.67, 6.72] | <0.00001 | RE: 1.00 [0.97, 1.03] | 0.98 |
| FE: 3.75 [2.93, 4.57] | <0.00001 | FE: 1.00 [0.96, 1.04] | 0.95 | |
| Mansfield et al. 2004 | RE: 5.45 [3.90, 7.00] | <0.00001 | RE: 1.01 [0.97, 1.04] | 0.74 |
| FE: 3.89 [3.08, 4.70] | <0.00001 | FE: 1.01 [0.97, 1.05] | 0.77 | |
| Bradley et al. 2005 | RE: 5.63 [4.25, 7.00] | <0.00001 | RE: 1.00 [0.97, 1.03] | 0.98 |
| FE: 5.15 [4.14, 6.17] | <0.00001 | FE: 1.00 [0.96, 1.03] | 0.86 | |
| Usui et al. 2005 | RE: 5.37 [3.85, 6.89] | <0.00001 | RE: 1.00 [0.97, 1.03] | 0.98 |
| FE: 3.89 [3.08, 4.69] | <0.00001 | FE: 1.00 [0.96, 1.04] | 0.95 | |
| Arzt et al. 2005 | RE: 5.55 [3.99, 7.12] | <0.00001 | RE: 1.00 [0.97, 1.03] | 0.98 |
| FE: 3.94 [3.12, 4.76] | <0.00001 | FE: 1.00 [0.96, 1.04] | 0.95 | |
| Egea et al. 2008 | RE: 5.64 [4.04, 7.24] | <0.00001 | RE: 1.00 [0.96, 1.03] | 0.79 |
| FE: 4.01 [3.17, 4.85] | <0.00001 | FE: 1.00 [0.96, 1.04] | 0.96 | |
| Johnson et al. 2008 | RE: 5.43 [3.86, 7.00] | <0.00001 | RE: 1.00 [0.97, 1.03] | 0.98 |
| FE: 3.87 [3.06, 4.69] | <0.00001 | FE: 1.00 [0.96, 1.04] | 0.95 | |
| Ferrier et al. 2008 | RE: 5.45 [3.88, 7.01] | <0.00001 | RE: 1.00 [0.97, 1.03] | 0.98 |
| FE: 3.88 [3.07, 4.70] | <0.00001 | FE: 1.00 [0.96, 1.04] | 0.95 | |
| Pepperell et al. 2003 | RE: 5.50 [3.97, 7.03] | <0.00001 | RE: 1.00 [0.97, 1.03] | 0.98 |
| FE: 3.92 [3.12, 4.73] | <0.00001 | FE: 1.00 [0.96, 1.04] | 0.95 | |
| Koyama et al. 2010 | RE: 5.04 [3.58, 6.49] | <0.00001 | RE: 1.00 [0.97, 1.03] | 0.98 |
| FE: 3.74 [2.92, 4.55] | <0.00001 | FE: 1.00 [0.96, 1.04] | 0.95 | |
| Hastings et al. 2010 | RE: 5.09 [3.65, 6.54] | <0.00001 | RE: 1.00 [0.97, 1.03] | 0.98 |
| FE: 3.80 [3.00, 4.61] | <0.00001 | FE: 1.00 [0.96, 1.04] | 0.95 | |
| Oldenburg et al. 2011 | RE: 5.60 [3.91, 7.29] | <0.00001 | RE: 1.00 [0.97, 1.04] | 0.79 |
| FE: 3.90 [3.02, 4.79] | <0.00001 | FE: 1.01 [0.96, 1.05] | 0.78 | |
| Koyama et al. 2011 | RE: 5.21 [3.67, 6.75] | <0.00001 | RE: 1.00 [0.97, 1.03] | 0.98 |
| FE: 3.70 [2.87, 4.53] | <0.00001 | FE: 1.00 [0.96, 1.04] | 0.95 | |
| Haruki et al. 2011 | RE: 5.23 [3.71, 6.74] | <0.00001 | RE: 1.00 [0.97, 1.03] | 0.98 |
| FE: 3.82 [3.01, 4.63] | <0.00001 | FE: 1.00 [0.96, 1.04] | 0.95 | |
| Yoshihisa et al. 2011 | RE: 5.33 [3.79, 6.88] | <0.00001 | RE: 1.00 [0.97, 1.03] | 0.86 |
| FE: 3.84 [3.03, 4.65] | <0.00001 | FE: 1.00 [0.96, 1.04] | 0.87 | |
| Joho et al. 2012 | RE: 4.95 [3.52, 6.38] | <0.00001 | RE: 1.00 [0.97, 1.03] | 0.98 |
| FE: 3.69 [2.87, 4.50] | <0.00001 | FE: 1.00 [0.96, 1.04] | 0.95 | |
LVEF: left ventricular ejection fraction; MD: mean difference; RR: risk ratio; RE: random effect model; FE: fixed effect model.