Table 1.
Demographic information for MDD patients and the subgroup that underwent FDG-PET imaging.
| All subjects N = 52 |
FDG-PET subgroup N = 20 |
|||
|---|---|---|---|---|
| Mean | SD | Mean | SD | |
| Age | 48.29 | 12.84 | 47.80 | 11.79 |
| Age of onset of first depressive episode | 19.92 | 11.84 | 21.30 | 12.97 |
| Length of current episode (months) | 86.88 | 124.12 | 115.90 | 161.04 |
| Number of failed treatment trials | 7.54 | 4.31 | 7.70 | 4.14 |
| Baseline SHAPS | 37.69 | 6.67 | 37.20 | 6.13 |
| Baseline MADRS | 33.12 | 4.78 | 33.10 | 5.67 |
| BMI | 30.01 | 6.30 | 29.60 | 4.34 |
|
| ||||
| N | % | N | % | |
|
| ||||
| Caucasian | 49 | 94 | 20 | 100 |
| Clinically significant anhedonia (Snaith et al., 1995)a | 45 | 87 | 18 | 90 |
| Comorbid anxiety disorder | 30 | 59 | 11 | 55 |
| Female | 19 | 37 | 6 | 30 |
| Family history of alcohol use disorderb | 19 | 37 | 4 | 20 |
| Family history of mood disorder | 44 | 85 | 18 | 90 |
| Melancholic | 16 | 33 | 8 | 44 |
| Currently smoking (nicotine) | 7 | 13 | 2 | 10 |
MDD: major depressive disorder; FDG-PET: [18F]-fluorodeoxyglucose positron emission tomography; SHAPS, Snaith-Hamilton Pleasure Scale; MADRS: Montgomery-Åsberg Depression Rating Scale; BMI: body mass index.
a
Clinically significant anhedonia was defined as scoring three or more items on the SHAPS with a value of 3 (disagree) or 4 (strongly disagree), as per the classification suggested by Snaith et al. (1995).
b
Family history of alcohol use disorder was defined as having a first-degree relative meeting criterion on the Family Interview for Genetic Studies.