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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Int J Cancer. 2016 Jul 23;139(9):2012–2020. doi: 10.1002/ijc.30245

Fig. 1. Workflow of analysis strategy.

Fig. 1

Our analysis strategy included: - a genome-wide association study (GWAS) of individual SNPs with Breslow thickness (BT) (first-stage in MELARISK and second-stage in MDACC); - a pathway analysis of MELARISK and MDACC GWAS outcomes to identify pathways (defined by gene ontology categories) enriched in genes associated with BT; a SNP-SNP interaction analysis within BT-associated pathways to identify the interactive effect of genetic variants influencing BT.