Table 1.
ΔcheY3 lacks infectivity in mice via needle injectiona
| Strain | Dosage (spirochetes/mouse) | Number of Mice Infected |
|---|---|---|
| WT | 5 × 103 | 5/5 |
| ΔcheY3 | 5 × 103 | 0/5 |
| 1 × 106 | 0/5 | |
| cheY3+ | 5 × 104 | 2/2 |
a
C3H/HeN mice were injected intradermally using the indicated in vitro-grown spirochete clones. Mice were sacrificed four weeks post injection, and infectivity was determined by reisolation or detection of B. burgdorferi genomes by PCR from the murine ear skin, tibiotarsal joint, and bladder tissue samples. Doses shown are the actual number of spirochetes injected in each mouse.