Fig. 5.

Intestinal deletion of Mecp2 does not replicate Mecp2-null intestinal phenotype. a A group of 14 Mecp2-null animals (solid line) was compared with a group of 11 Mecp2 ^Δ3–4/y conditional knock-out mice (dashed line). Kolmogorov–Smirnov test demonstrated a better survival rate for the conditional knock-out animals over the Mecp2-null mice, P < 0.0005. Determinations of b colon length and c surface–crypt axis length showed no differences among groups (n = 5 for wild-type, n = 9 for Mecp2 ^Δ3–4/y, n = 4 for Mecp2 ^flox/y, and n = 6 for Vil-Cre)