Table 2.
Comparison of Cohort Characteristics Between Those Meeting 1, 2, 3, or 4 Left Ventricular Noncompaction Criteria
| Criteria Met | 0 | 1 | 2 | 3 | 4 | p Value∗ |
|---|---|---|---|---|---|---|
| N | 1,262 | 102 | 54 | 44 | 19 | |
| Male | 480 (38) | 47 (46) | 19 (35) | 16 (36) | 6 (32) | 0.64 |
| Age, yrs | 54.2 ± 8.2 | 53.9 ± 7.9 | 53.4 ± 9.0 | 53.5 ± 9.7 | 54.1 ± 8.6 | 0.97 |
| Pulse, beats/min | 63.4 ± 9.3 | 64.3 ± 16.1 | 62.3 ± 7.9 | 63.4 ± 10.7 | 60.3 ± 6.0 | 0.038 |
| Systolic BP, mm Hg | 123 ± 12 | 123 ± 12 | 120 ± 11 | 121 ± 11 | 118 ± 13 | 0.10 |
| Diastolic BP, mm Hg | 73 ± 9 | 73 ± 9 | 71 ± 9 | 70 ± 8 | 71 ± 9 | 0.44 |
| ASSIGN 10-yr risk score | 9.4 ± 6.7 | 8.9 ± 5.6 | 8.1 ± 5.5 | 9.4 ± 7.9 | 8.1 ± 5.2 | 0.42 |
| Height, m | 1.68 ± 0.09 | 1.68 ± 0.09 | 1.68 ± 0.08 | 1.70 ± 0.10 | 1.67 ± 0.09 | 0.69 |
| Weight, kg | 75.5 ± 14.5 | 76.1 ± 13.4 | 75.1 ± 14.1 | 75.3 ± 13.1 | 69.9 ± 12.1 | 0.09 |
| BMI, kg/m2 | 26.8 ± 4.3 | 26.9 ± 3.5 | 26.7 ± 4.6 | 26.1 ± 3.7 | 25.0 ± 3.0 | 0.019 |
| Current smoker | 152 (12) | 9 (9) | 5 (9) | 3 (7) | 0 (0) | 0.15 |
| Ex smoker | 328 (26) | 30 (29) | 15 (28) | 18 (39) | 5 (26) | 1.00 |
| Nonsmoker | 482 (62) | 61 (61) | 34 (63) | 23 (52) | 14 (68) | 0.64 |
| Smoking pack-yrs | 6.0 ± 11.7 | 8.2 ± 16.5 | 4.7 ± 9.1 | 4.6 ± 8.2 | 6.3 ± 12.9 | 0.90 |
| FH of CVD | 328 (26) | 26 (25) | 13 (24) | 12 (27) | 6 (32) | 0.60 |
| Total cholesterol, mmol/l | 5.49 ± 0.98 | 5.28 ± 0.78 | 5.38 ± 0.85 | 5.60 ± 1.21 | 5.33 ± 0.96 | 0.48 |
| LDL cholesterol, mmol/l | 3.40 ± 0.88 | 3.27 ± 0.76 | 3.27 ± 0.72 | 3.51 ± 1.11 | 3.43 ± 0.81 | 0.88 |
| HDL cholesterol, mmol/l | 1.44 ± 0.43 | 1.39 ± 0.42 | 1.46 ± 0.38 | 1.43 ± 0.42 | 1.44 ± 0.37 | 0.95 |
| Triglycerides, mmol/l | 1.48 ± 0.86 | 1.39 ± 0.79 | 1.51 ± 1.01 | 1.51 ± 0.91 | 1.19 ± 0.59 | 0.15 |
| Random glucose, mmol/l | 5.18 ± 0.92 | 5.18 ± 0.69 | 4.99 ± 0.81 | 5.25 ± 0.97 | 5.38 ± 0.42 | 0.56 |
| BNP, pg/ml | 27.5 ± 15.6 | 24.1 ± 13.8 | 29.4 ± 20.5 | 32.8 ± 27.3 | 31.0 ± 23.4 | 0.39 |
Values are N, n (%) or mean ± SD. N for diagnostic criteria met is mutually exclusive, and based on the maximum number of criteria met by each study participant.
ASSIGN = assessing cardiovascular risk using Scottish Intercollegiate Guidelines Network; BMI = body mass index; BP = blood pressure; BNP = B-type natriuretic peptide; CVD = cardiovascular disease; FH = family history; HDL = high-density lipoprotein; LDL = low-density lipoprotein.
p values are derived from comparing those meeting 0 criteria and those meeting all 4 criteria, with binary outcome variables compared using the Fisher exact test. Significance level set at p = 0.0025 after Bonferroni correction for multiple comparisons.