Table 2.

Effects of age, WMH volume, and ApoE on the FDG-PET uptake in WMHs.

Independent variables	Dependent variables
	FDG-PET uptake in WMHs
	Aβ(+)			Aβ(−)
	Beta	p	R2	Beta	p	R2
WMH volume	0.187	0.369	0.030	−0.278	0.259	0.075
Age	−0.071	0.732		0.069	0.776
WMH volume	0.133	0.533		−0.269	0.301
Age	−0.054	0.795	0.067	0.064	0.800	0.076
Sex	0.198	0.322		0.034	0.895
WMH volume	0.138	0.500		−0.353	0.177
Age	−0.041	0.842	0.063	0.072	0.767	0.126
ApoE4	0.20	0.300		−0.24	0.351

Associations between age, WMH volume, and ApoE, and the WMH FDG-PET uptake were determined by means of linear regression.

FDG-PET, [¹⁸F]-fluorodeoxyglucose positron emission tomography; WMH, white matter hyperintensity; Aβ, amyloid β-peptide; ApoE4, apolipoprotein E4.