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. 2016 Oct 21;23(11):400–409. doi: 10.1038/cgt.2016.53

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Copyright © 2016 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Magnetic resonance imaging (MRI) and histopathological findings of case 13 in dose level-4 (DL-4) treated by three track injections with 3x10¹² vp of Ad-REIC. (a) Contrast enhancement MRIs. A strong enhancement area indicated by an arrow before Ad-REIC injections disappeared after injections. (b and c) Low and high magnification photomicrographs. Whole targeted cancer area is replaced by degenerated cancer cells with remarkable tumor-infiltrating lymphocytes (TILs). The inset shows gross appearance of hematoxylin and eosin (H&E)-stained histopathological sections.