Table 4B. Quantitative kinetic analysis of adenoviral DNA in urine by real-time PCR.
| Day 0 | Day 1 | Day 3 | Day 15 | Day 17 | Day 56 | |
|---|---|---|---|---|---|---|
| Adenoviral DNA quantity in urine (copies per ml) | ||||||
| DL-1 | ||||||
| 1 | ND* | ND* | ND* | ND* | ND* | ND* |
| 2 | ND* | ND* | ND* | ND* | ND* | ND* |
| 3 | ND* | ND* | ND* | ND* | ND* | ND* |
| DL-2 | ||||||
| 4 | ND* | ND* | ND* | ND* | — | ND* |
| 5 | ND* | ND* | ND* | ND* | ND* | ND* |
| 6 | ND* | ND* | ND* | ND* | ND* | ND* |
| DL-3 | ||||||
| 7 | 2.9 × 103 | 2.8 × 103 | 5.7 × 102 | 5.5 × 103 | 7.0 × 103 | ND* |
| 8 | ND* | 1.2 × 102 | ND* | ND* | ND* | ND* |
| 9 | ND* | ND* | ND* | 7.9 × 102 | ND* | ND* |
| 10 | ND* | ND* | ND* | ND* | ND* | ND* |
| 11 | ND* | 1.2 × 102 | ND* | ND* | ND* | ND* |
| 12 | ND* | 3.7 × 102 | ND* | 1.2 × 102 | — | ND* |
| DL-4 | ||||||
| 13 | ND* | ND* | ND* | 1.2 × 103 | ND* | ND* |
| 14 | ND* | 1.1 × 102 | ND* | 2.1 × 102 | ND* | ND* |
| 15 | ND* | 2.2 × 103 | ND* | 3.2 × 102 | ND* | ND* |
| 16 | ND* | 6.5 × 103 | 1.6 × 103 | 3.7 × 104 | ND* | ND* |
| 17 | ND* | ND* | ND* | 1.5 × 104 | ND* | ND* |
| 18 | ND* | 3.5 × 103 | 6.3 × 103 | 1.7 × 102 | ND* | ND* |
Abbreviations: DL, dose level; ND, not detected; —, not measured.
*ND: <1.0 × 102 copies per ml.