Table 4.
Association between cutaneous human papillomavirus (HPV) infection in eyebrow hair and the risk of subsequent squamous cell carcinoma (SCC).
| Eyebrow hair viral infection | No subsequent SCC (n = 59) |
Subsequent SCC (n = 91) | ∗HR (95% CI) |
|---|---|---|---|
| at the index SCC diagnosis | |||
| Any beta HPV 1 | |||
| DNA negative | 6 (10.5) | 12 (13.6) | 1.00 |
| DNA positive | 51 (89.5) | 76 (86.4) | 0.84 (0.45–1.56) |
| Any beta 1 HPV 2 | |||
| DNA negative | 6 (13.6) | 12 (16.2) | 1.00 |
| DNA positive | 38 (86.4) | 62 (83.8) | 0.84 (0.44–1.58) |
| Any beta 2 HPV 3 | |||
| DNA negative | 6 (12.0) | 12 (16.2) | 1.00 |
| DNA positive | 44 (88.0) | 62 (83.8) | 0.85 (0.45–1.59) |
| Multiple beta 1 HPV 4 | |||
| DNA negative | 25 (56.8) | 37 (50.0) | 1.00 |
| DNA positive | 19 (43.2) | 37 (50.0) | 1.18 (0.72–1.93) |
| Multiple beta 2 HPV 5 | |||
| DNA negative | 29 (58.0) | 35 (47.3) | 1.00 |
| DNA positive | 21 (42.0) | 39 (52.7) | 1.23 (0.75–2.01) |
1Eyebrow hair DNA positive to any beta HPV type versus negative to all 25 beta HPV types. 2Eyebrow hair DNA positive to at least one beta 1 HPV type versus DNA negative to 25 beta HPV types. 3Eyebrow hair DNA positive to at least one beta 2 HPV type versus DNA negative to 25 beta HPV types. 4Eyebrow hair DNA positive to 2 or more beta-1 HPV types versus DNA negative to 25 beta HPV types or positive to one beta 1 HPV type. 5Eyebrow hair DNA positive to 2 or more beta 2 HPV types versus DNA negative to 25 beta HPV types or positive to one beta 2 HPV type. HR = hazards ratio, CI = confidence interval. ∗Adjusted for age and gender.