Table 5.
Association of beta HPV infection in eyebrow hair and beta HPV seropositivity with the risk of subsequent SCC by index tumor HPV DNA status.
| Viral infection at the time of index SCC diagnosis |
HPV DNA negative index SCC | HPV DNA positive index SCC | ||||
|---|---|---|---|---|---|---|
| No subsequent SCC (n = 23) | Subsequent SCC (n = 22) | HR (95% CI) |
No subsequent SCC (n = 31) | Subsequent SCC (n = 55) | HR (95% CI) |
|
| HPV serology | ||||||
| Any beta HPV 1,3 | ||||||
| Beta HPV seronegative | 7 (30.4) | 10 (45.5) | 1.00 | 7 (22.6) | 12 (21.8) | 1.00 |
| Beta HPV seropositive | 16 (69.6) | 12 (54.5) | 0.44 (0.18–1.03) | 24 (77.4) | 43 (78.9) | 0.92 (0.48–1.75) |
| HPV infection in eyebrow hairs | ||||||
| Any beta HPV 2,3 | ||||||
| DNA negative to all beta HPV types | 3 (13.6) | 6 (27.3) | 1.0 | 2 (6.7) | 5 (9.4) | 1.0 |
| DNA positive to ≥1 beta HPV | 19 (86.4) | 16 (72.7) | 0.97 (0.38–2.50) | 28 (93.3) | 48 (90.6) | 0.30 (0.11–0.78) |
| Any beta 1 HPV 4 | ||||||
| DNA negative | 3 (25.00) | 6 (33.3) | 1.0 | 2 (11.1) | 1 (2.8) | 1.0 |
| DNA positive | 9 (75.0) | 12 (66.7) | 1.21 (0.45–3.24) | 16 (88.9) | 35 (97.2) | 0.72 (0.09–5.45) |
| Any beta 2 HPV 4 | ||||||
| DNA negative | 3 (15.0) | 6 (35.3) | 1.0 | 1 (4.8) | 5 (12.8) | 1.0 |
| DNA positive | 17 (85.0) | 11 (64.7) | 0.85 (0.31–2.32) | 20 (95.2) | 34 (87.2) | 0.32 (0.12–0.86) |
1Any beta HPV seropositivity was defined as seropositive to ≥1 beta HPV types versus seronegative to all beta HPV types. 2Any beta HPV infection in eyebrow hairs was defined as DNA positivity to ≥1 beta HPV types versus DNA negativity to all beta HPV types. 3Tumor DNA status was defined as DNA positive to one or more beta HPV types versus DNA negative to all beta HPV types. 4Tumor DNA status was defined as DNA positivity to species-specific beta HPV types versus DNA negative to all beta HPV types.