Table 6.

Clinical correlates in 2611 recent-onset Parkinson's disease cases according to the use of statin medication stratified by the presence of future cardiovascular risk and existing cardiovascular disease

	Vascular disease, n=375				QRISK2 ≥10%, n=1646
Variable	Statin use, n=280	No statin use, n=95	Unadjusted p value	Adjusted p value	Statin use, n=450	No statin use, n=1196	Unadjusted p value	Adjusted p value
Age	72.5 (7.2)	72.0 (8.7)	0.57	0.60*	71.4 (6.6)	70.0 (6.4)	<0.001	<0.001*
Sex	221 (78.9%)	63 (66.3%)	0.014	0.017†	340 (75.6%)	840 (70.2%)	0.033	0.004†
Disease duration	1.4 (1.0)	1.2 (0.8)	0.071	0.078‡	1.3 (1.0)	1.3 (0.9)	0.76	0.60‡
UPDRS 3	26.8 (12.3)	26.5 (12.2)	0.82	0.89§	24.9 (11.6)	23.9 (11.7)	0.17	0.81§
Motor subtype
TD	108 (42.0%)	29 (34.1%)			230 (54.1%)	530 (47.7%)
PIGD	116 (45.1%)	48 (56.5%)	0.11	0.16§	144 (33.9%)	434 (39.1%)	0.031	0.009§
Mixed	33 (12.8%)	8 (9.4%)	0.82	0.58§	51 (12.0%)	147 (13.2%)	0.22	0.39§
MoCA
Total	24.2 (3.6)	23.9 (3.3)	0.48	0.23§	24.0 (3.8)	25.1 (3.4)	<0.001	<0.001§
Normal	169 (63.3%)	47 (51.6%)	0.095	0.043§	249 (59.6%)	831 (73.8%)	<0.001	<0.001§
MCI	42 (15.7%)	22 (24.2%)			75 (17.9%)	149 (13.2%)
Dementia	56 (21.0%)	22 (24.2%)			94 (22.5%)	146 (13.0%)
LEDD	317 (210)	304 (176)	0.57	0.57§	275 (203)	294 (206)	0.11	0.025§
Smoking
Non-smoker	109 (44.7%)	49 (56.3%)	0.12	0.20§	215 (52.1%)	611 (55.1%)	0.31	0.41§
Ex-smoker	127 (52.0%)	33 (37.9%)			183 (44.3%)	457 (41.2%)
Current smoker	8 (3.3%)	5 (5.7%)			15 (3.6%)	40 (3.6%)

Data are mean (SD) or number (percentage) unless otherwise stated.

*Adjusted for disease duration and sex.

†Adjusted for age and disease duration.

‡Adjusted for age and sex.

§Adjusted for age, sex, disease duration and coffee use.

MCI, mild cognitive impairment; MoCA, Montreal cognitive assessment; PIGD, postural instability gait difficulty; TD, tremor dominant; UPDRS 3, Movement Disorder Society unified Parkinson's disease rating scale part 3.