Table 4.
Interactions between herbicides and SNPs with prostate cancer risk (p < 0.01).
| Exposure |
None |
Low exposure |
High exposure |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP | Pesticide | Genotype | Ca/Co | REF | Ca/Co | OR (95% CI) | Ca/Co | OR (95% CI) | p-inta | q-valueb | |
| Hormonal pathway | Gene | ||||||||||
| rs8192166 | SRD5A1 | Dicamba | CC | 133/173 | 1.0 | 64/131 | 0.62 (0.41, 0.93) | 49/142 | 0.44 (0.29, 0.68) | 4.0 × 10−5 | 0.03 |
| CT + TT | 189/396 | 1.0 | 108/229 | 0.95 (0.69, 1.30) | 127/218 | 1.15 (0.85, 1.57) | |||||
| rs3798577 | ESR1 | Butylate | TT | 162/256 | 1.0 | 10/42 | 0.40 (0.19, 0.83) | 8/42 | 0.30 (0.14, 0.66) | 8.0 × 10−5 | 0.12 |
| CT + CC | 338/647 | 1.0 | 42/110 | 0.74 (0.50, 1.08) | 64/97 | 1.28 (0.90, 1.80) | |||||
| Hormone GWAS | Affected hormone | ||||||||||
| rs4784336 | SHBG | Dicamba | AA | 258/473 | 1.0 | 130/273 | 0.87 (0.65, 1.15) | 152/274 | 1.00 (0.76, 1.32) | 3.7 × 10−3 | 0.90 |
| AC + CC | 66/98 | 1.0 | 42/87 | 0.65 (0.39, 1.08) | 24/87 | 0.36 (0.20, 0.65) | |||||
| rs1017993 | DHEAS | Alachlor | CC | 182/406 | 1.0 | 135/282 | 1.07 (0.81, 1.41) | 147/273 | 1.21 (0.92, 1.58) | 9.2 × 10−3 | 1.00 |
| CT + TT | 95/140 | 1.0 | 65/106 | 0.92 (0.61, 1.40) | 47/113 | 0.60 (0.39, 0.93) | |||||
ORs adjusted for age and state.
aStrata with less than five observations per cell or qualitative interactions excluded. Interactions that were statistically significant (p-int < 0.01) and for which there was a significant association between the pesticide and SNP (p < 0.05) with a monotonic pattern in at least one genotype stratum are included in table.
bThe q-value adjusts the p-value for multiple statistical comparisons using the false discovery rate (FDR) method.