TABLE 1.
Apparent KD of the interaction of A1 subunits with ribosomes
| Toxin | Mean apparent KD (M) of ribosomesa |
|
|---|---|---|
| Yeast | Rat | |
| Stx1A1 | ||
| WT | 8.47 × 10−8 ± 0.15 × 10−8A | 9.39 × 10−8 ± 2.03 × 10−8E |
| R170A | 9.37 × 10−8 ± 0.23 × 10−8B | 11.71 × 10−8 ± 1.91 × 10−8F |
| Stx2A1 | ||
| WT | 2.89 × 10−8 ± 0.08 × 10−8C | 4.39 × 10−8 ± 0.15 × 10−8G |
| R170A | 3.45 × 10−8 ± 0.22 × 10−8D | 5.06 × 10−8 ± 0.83 × 10−8H |
a
The letters indicate statistical comparisons, where means were significantly different between A and B (P < 0.01), between C and D (P < 0.05), between B and D (P < 0.001), between E and F (P < 0.05), between G and H (P < 0.05), and between F and H (P < 0.001) as determined using a two-sample t test.